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2003 1
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2014 6
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Page 1
Dual Outcomes of Rosiglitazone Treatment on Fatty Liver.
Gao M, Ma Y, Alsaggar M, Liu D. Gao M, et al. AAPS J. 2016 Jul;18(4):1023-31. doi: 10.1208/s12248-016-9919-9. Epub 2016 Apr 28. AAPS J. 2016. PMID: 27125895
Using a gene transfer approach and mice fed a high-fat diet (HFD) as an animal model, we demonstrate that mice with low levels of PPAR-gamma expression in the liver are resistant to HFD-induced development of fatty liver when treated with rosiglitazone. ...Th …
Using a gene transfer approach and mice fed a high-fat diet (HFD) as an animal model, we demonstrate that mice with low levels of PPAR-gamma …
Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet.
Gao M, Ma Y, Cui R, Liu D. Gao M, et al. J Control Release. 2014 Jul 10;185:1-11. doi: 10.1016/j.jconrel.2014.03.047. Epub 2014 Apr 18. J Control Release. 2014. PMID: 24747761 Free PMC article.
We demonstrate that transfer of the FGF21 gene using a hydrodynamics-based procedure increased mRNA levels of FGF21 exclusively in the liver, consequently generating a sustained high level of FGF21 protein in blood that peaked at 500 ng/ml 1 day after injection, leading to …
We demonstrate that transfer of the FGF21 gene using a hydrodynamics-based procedure increased mRNA levels of FGF21 exclusively in the li …
Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis.
Lee YJ, Kim JW. Lee YJ, et al. BMB Rep. 2017 Jul;50(7):367-372. doi: 10.5483/bmbrep.2017.50.7.036. BMB Rep. 2017. PMID: 28347400 Free PMC article.
However, the subcellular localization and catalytic function domain of this enzyme is poorly understood. In this report, we identified that murine MGAT1 localizes to the endoplasmic reticulum (ER) under normal conditions, whereas MGAT1 co-localize to the lipid dropl …
However, the subcellular localization and catalytic function domain of this enzyme is poorly understood. In this report, we identified that …
Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism.
Chalhoub G, Jamnik A, Pajed L, Kolleritsch S, Hois V, Bagaric A, Prem D, Tilp A, Kolb D, Wolinski H, Taschler U, Züllig T, Rechberger GN, Fuchs C, Trauner M, Schoiswohl G, Haemmerle G. Chalhoub G, et al. Mol Metab. 2023 Jun;72:101725. doi: 10.1016/j.molmet.2023.101725. Epub 2023 Apr 12. Mol Metab. 2023. PMID: 37059417 Free PMC article.
Recent studies showed decreased expression of carboxylesterase 2 (CES2) in the liver of NASH patients and hepatic DAG accumulation was linked to low CES2 activity in obese individuals. ...Lipidomic analysis revealed a marked rise in DAG and lysoPC levels in the liver …
Recent studies showed decreased expression of carboxylesterase 2 (CES2) in the liver of NASH patients and hepatic DAG accumulation wa …
Regular moderate aerobic exercise improves high-fat diet-induced nonalcoholic fatty liver disease via monoacylglycerol O-acyltransferase 1 pathway suppression.
Baek KW, Gim JA, Park JJ. Baek KW, et al. J Sport Health Sci. 2020 Sep;9(5):472-478. doi: 10.1016/j.jshs.2018.09.001. Epub 2018 Sep 8. J Sport Health Sci. 2020. PMID: 32928450 Free PMC article.
PURPOSE: Monoacylglycerol O-acyltransferase 1 (MGAT1) is reported to play a key role in the development of diet-induced nonalcoholic fatty liver disease (NAFLD). ...The 6-week regular moderate aerobic exercise consisted of an accommodation phase with increasi …
PURPOSE: Monoacylglycerol O-acyltransferase 1 (MGAT1) is reported to play a key role in the development of diet-induced nonalcoholic …
MOGAT2: A New Therapeutic Target for Metabolic Syndrome.
Yang M, Nickels JT. Yang M, et al. Diseases. 2015 Aug 28;3(3):176-192. doi: 10.3390/diseases3030176. Diseases. 2015. PMID: 28943619 Free PMC article. Review.
It is a group of intertwined maladies that includes obesity, hypertriglyceridemia, hypertension, nonalcoholic fatty liver disease (NAFLD), and diabetes mellitus type II (T2D). ...The Acyl-CoA: monoacylglycerolacyltransferase (MGAT) family has three members (MGAT1 …
It is a group of intertwined maladies that includes obesity, hypertriglyceridemia, hypertension, nonalcoholic fatty liver dise …
Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice.
Hall AM, Soufi N, Chambers KT, Chen Z, Schweitzer GG, McCommis KS, Erion DM, Graham MJ, Su X, Finck BN. Hall AM, et al. Diabetes. 2014 Jul;63(7):2284-96. doi: 10.2337/db13-1502. Epub 2014 Mar 4. Diabetes. 2014. PMID: 24595352 Free PMC article.
The expression of genes that encode MGAT enzymes is induced in the livers of insulin-resistant human subjects with nonalcoholic fatty liver disease, but whether MGAT activation is causal of hepatic steatosis or insulin resistance is unknown. We show that the express …
The expression of genes that encode MGAT enzymes is induced in the livers of insulin-resistant human subjects with nonalcoholic fatty …
Monoacylglycerol Acyltransferase 1 Knockdown Exacerbates Hepatic Ischemia/Reperfusion Injury in Mice With Hepatic Steatosis.
Liss KHH, Ek SE, Lutkewitte AJ, Pietka TA, He M, Skaria P, Tycksen E, Ferguson D, Blanc V, Graham MJ, Hall AM, McGill MR, McCommis KS, Finck BN. Liss KHH, et al. Liver Transpl. 2021 Jan;27(1):116-133. doi: 10.1002/lt.25886. Epub 2020 Oct 22. Liver Transpl. 2021. PMID: 32916011 Free PMC article.
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common indication for liver transplantation. ...Herein, we sought to determine whether Mogat1 (the gene encoding MGAT1) knockdown in mice with hepatic steatosis would reduce liver inj …
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common indication for liver transplantation. ...Herein, w …
Chlorogenic acid improves glucose tolerance, lipid metabolism, inflammation and microbiota composition in diabetic db/db mice.
Yan Y, Li Q, Shen L, Guo K, Zhou X. Yan Y, et al. Front Endocrinol (Lausanne). 2022 Nov 17;13:1042044. doi: 10.3389/fendo.2022.1042044. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36465648 Free PMC article.
METHODS: In the current study, diabetic db/db mice were administered CGA or metformin, and db/m mice were used as controls to explore the effects of CGA on hepatic lipid metabolism, including fatty acid oxidation and transportation and triglyceride (TG) lipolysis and synth …
METHODS: In the current study, diabetic db/db mice were administered CGA or metformin, and db/m mice were used as controls to explore the ef …
Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis.
Alsanea S, Gao M, Liu D. Alsanea S, et al. AAPS J. 2017 May;19(3):797-805. doi: 10.1208/s12248-017-0053-0. Epub 2017 Feb 14. AAPS J. 2017. PMID: 28197827
The effects of phloretin treatment on body weight and composition, fat content in the liver, glucose and lipid metabolism, and insulin resistance were monitored and compared to the control animals. ...RT-PCR analysis showed that phloretin treatment suppresses expression of …
The effects of phloretin treatment on body weight and composition, fat content in the liver, glucose and lipid metabolism, and insuli …
26 results